An American scientist up to no good (as usual) by creating the half-pterodactyl, half-barracuda: Pteracuda. When the creature inevitably escapes, it's up to Sharktopus to stop him.
Aspiring college cheerleader, Cassie Stratford consumes an experimental drug that grants her beauty and enough athletic ability to make the cheer squad. The drug has an unforeseen side effect — Cassie starts to grow and grow and grow!