Vampires Galen and Miranda have just moved to Los Angeles. Galen wants to lay low and get his blood from a nearby blood bank while Miranda likes hers fresh, young, and virile. When Galen notices dancer Jennifer in the apartment next door, he falls in love and sets out to pursue her. Miranda becomes jealous and seduces Jennifer, too, while Jennifer's cop boyfriend Ryan senses that she is becoming too friendly with Galen and Miranda. Meanwhile, Ryan and Detective Turner have their hands full trying to figure out why bloodless bodies keep turning up with two puncture wounds on the neck.
Seth Gecko and his younger brother Richard are on the run after a bloody bank robbery in Texas. They escape across the border into Mexico and will be home-free the next morning, when they pay off the local kingpin. They just have to survive 'from dusk till dawn' at the rendezvous point, which turns out to be a Hell of a strip joint.
Fresh to Las Vegas with no connections, Nomi Malone takes a job as an exotic dancer. Her talents are quickly noticed by Cristal, a headlining dancer who senses an opportunity to bolster her own act. But Nomi won’t play second fiddle and soon begins her venomous path to the top, ruthlessly backstabbing anyone who gets in her way.