Schoolteacher Bertram Cates is arrested for teaching his students Darwin's theory of evolution. The case receives national attention and one of the newspaper reporters, E.K. Hornbeck, arranges to bring in renowned defense attorney and atheist Henry Drummond to defend Cates. The prosecutor, Matthew Brady is a former presidential candidate, famous evangelist, and old adversary of Drummond.
A backwoods game warden and a local doctor discover that giant leeches are responsible for disappearances and deaths in a local swamp, but the local police don't believe them.
A former model, serving time in prison, becomes a key witness in a trial against a notorious gangster. She is put under protective watch by the District Attorney in a posh hotel, but the crime kingpin makes attempts to get to her.