The life of a young man growing up in a small town in the mountains of North Carolina during the early part of the 20th century, based on Thomas Wolfe's autobiographical novel of the same name.
Cleve Marshall is an assistant district attorney who falls for the shadowy Thelma Jordon. With her sordid past -- and her relationship with thief Tony Laredo kept secret from the married attorney, Jordon seduces the easily swayed Marshall, and uses him to cover up her misdeeds. When Jordon becomes the prime suspect for the murder of her wealthy aunt, she turns to Marshall, who goes to great lengths to clear her name.
Evelyn, an emotionally vulnerable and unstable woman, stays at the home of her doctor Dan Proctor. There she meets and falls in love with his brother, Douglas, who is happily married to Ann. Evelyn then sets forth to break up the happy marriage and win the love of Douglas.
Romanian-French gigolo Georges Iscovescu wishes to enter the USA. Stopped in Mexico by the quota system, he decides to marry an American, then desert her and join his old partner Anita, who's done likewise. But after sweeping teacher Emmy Brown off her feet, he finds her so sweet that love and jealousy endanger his plans.