When a car bomb explodes on the American side of the U.S./Mexico border, Mexican drug enforcement agent Miguel Vargas begins his investigation, along with American police captain Hank Quinlan. When Vargas begins to suspect that Quinlan and his shady partner, Menzies, are planting evidence to frame an innocent man, his investigations into their possible corruption quickly put himself and his new bride, Susie, in jeopardy.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
At the Brentwood Asylum for the mentally ill, psychiatrist partners Jane Everest and Alex MacGregor are broken up by the new superintendent, Dr. Charles Monet, who has a low regard for women physicians. Jane and Charles clash on patient treatment, and Jane learns that Charles has a sister, Claire, with a mysterious past.
The dream of Paul Dombey, the wealthy owner of the shipping company, is to have a son to continue his business. Tragically, Dombey's wife dies shortly after giving birth to their son.
A year after their former exploits, Tom Sawyer's puppy love of Becky Thatcher keeps him home while Huck Finn, chafing under "civilizing" influences like school and shoes, plans to run away. His scapegrace, abusive father intervenes; Tom and black Jim help him escape; and (departing from the novel) all three raft down the Mississippi, where they're joined by two likable rogues and meet pretty orphans Ella and Mary Jane. The latter may change Huck's mind about girls...