In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.
After an abrupt and violent encounter with a French warship inflicts severe damage upon his ship, a captain of the British Royal Navy begins a chase over two oceans to capture or destroy the enemy, though he must weigh his commitment to duty and ferocious pursuit of glory against the safety of his devoted crew, including the ship's thoughtful surgeon, his best friend.