Desperate to save his family from death threats by a notorious drug dealer, Mateo Cruz steals the venerated image of the Virgin of Guadalupe causing pandemonium throughout Mexico.
Frantic to be free of Felix, her wealthy but drunken and violent drug-lord husband, Ana tricks her fresh-from-prison sister, Aurora, and two other ex-partners in crime into coming to her aid. Now that their crew is reassembled, the women begin planning a heist that will rid Ana of Felix and net them enough cash to be set for life.