Set against the backdrop of the prescription drug and opioid crisis in the USA, Jamie Sisley depicts the individual consequences of a societal tragedy, while taking an unflinching yet gentle look at a complicated web of relationships.
Sent to the Berkshires to focus on his next album, disillusioned rap star Money Merc abruptly announces his retirement on Twitter. After Merc's announcement, his manager rushes to the countryside to lure him back into the music industry.
Pennsylvania, 1993. After getting caught with another girl, teenager Cameron Post is sent to a conversion therapy center run by the strict Dr. Lydia Marsh and her brother, Reverend Rick, whose treatment consists in repenting for feeling “same sex attraction.” Cameron befriends fellow sinners Jane and Adam, thus creating a new family to deal with the surrounding intolerance.
Bob, a 50-year-old logger in rural Massachusetts with a soft spot for golf and gangsta rap, is struggling to make ends meet in a changed economy. When his beloved cow is wounded and a job goes awry, Bob begins to heed the instincts of his ever-darkening self.
Gordon is a timid and lonely man that wants nothing more than the attention of Wendy and frequents the laundromat where she works just so he can be close to her. Wendy, on the other hand, has very little interest in Gordon. After Gordon receives some bad advice that the only way to turn on a woman like Wendy is to get her scared, he comes up with the perfect plan for a date: a late night trip into the woods where cannibalistic creatures known as the Melon Heads are rumored to live. Gordon is convinced that if he takes Wendy on the most terrifying date of her life, he'll finally win her attention and her heart.
