England has been overrun by a pandemic with no apparent cure. As the infection continues to spread, safety - for a lucky few - looms in the form of a damaged 747 set to seek solace abroad. It's only once the plane is airborne that the survivors discover the infection made it onto the flight with them.
Two lifelong friends bond whilst vacationing in a luxury Swiss Alps lodge as they ponder retirement. While Fred has no plans to resume his musical career despite the urging of his loving daughter Lena, Mick is intent on finishing the screenplay for what may be his last important film for his muse Brenda. And where will inspiration lead their younger friend Jimmy, an actor grasping to make sense of his next performance?