An emotionally disturbed teenager whose father is a research scientist takes a rat from his father's laboratory that is infected with an incurable virus that can kill 100 million people in three weeks.
Jake Remy leads a gang of outlaw cutthroats making their escape toward Mexico from a successful robbery. Barring their way is a river--crossable only by means of a ferry barge. The barge operator, Travis, refuses to be bullied into providing transport for the gang and escapes across river with most of the local populace--leaving Remy and his gang behind, desperately seeking a way across. A river-wide stand-off begins between the gang and the townspeople, both groups of which have left people on the wrong side of the river.
While crossing the desert, a frontier scout, Jess Remsberg, rescues Ellen Grange from a pursuing band of Apaches, and returns her to her husband, Willard Grange. He is contracted to act as a scout for an Army cavalry unit. Willard, Ellen, and her infant son are along for the ride, as is horse trader Toller, a veteran of the 10th Cavalry. The party is trapped in a canyon by Chata, an Apache chief and grandfather of Ellen's baby. Willard is captured and tortured. Jess sneaks away and brings reinforcements just in time to save the day. Jess learns that the man he has been hunting is none other than Willard Grange.
Expository internal affairs drama which brings to light the often unprincipled tactics used in negative "smear" campaigning, and its effects within the political arena.