Camden, who suffers from agoraphobia, the fear of open spaces, takes in roommate Randy Tommy Sweeney, who suffers from claustrophobia, the fear of closed spaces. Unfortunately, Randy turns out to be a serial killer, and Camden becomes a prisoner in his own apartment.
Dr. Lorca, an eccentric collector of biological oddities - has just "acquired" his greatest specimen: a horrible mutant born of toxic sewage, but the creature's rightful owner wants it back. The collector's clash is cut short though, as the sickening specimen comes to life, re-animating an angry, oozing little army of ferocious freaks