The idols of 765 Production continue on their neverending journey—towards a new stage, towards a bright and shiny future! The girls and their producer have gone through thick and thin, and have stood face to face with all kinds of difficulties. It's time again for the girls to foster their friendship, and through great discipline, they step forward to their starry future.
The year is 1939 - it was then that the Neuroi appeared. Nobody knows where they came from or what their ultimate agenda is, but the fact remains that their attacks drove people out of their towns and cities. In order to take arms against them, humanity develops a new anti-Neuroi weapon called the "Striker Unit." Using the power of magic to fight against the monsters, this new device enhances and amplifies the power of female magic-wielders. To use this device, young witches from all over the world have been brought together to form an elite task force unit called the 501st Joint Fighter Wing, commonly known as the "Strike Witches."
Seven years after the defeat of the spiral king, Simon and the Dai-Gurren brigade must set out to the vastness of space to defeat a new threat and save the universe.