William has a simple job: he makes dead bodies disappear. His daughter Gloria has become used to rough-looking men dropping off corpses, and is even convinced that some of them are haunting their house.
Extreme athlete turned government operative Xander Cage comes out of self-imposed exile, thought to be long dead, and is set on a collision course with deadly alpha warrior Xiang and his team in a race to recover a sinister and seemingly unstoppable weapon known as Pandora's Box. Recruiting an all-new group of thrill-seeking cohorts, Xander finds himself enmeshed in a deadly conspiracy that points to collusion at the highest levels of world governments.