Seven years on from the events of Monsters, and the ‘Infected Zones’ have spread worldwide. Humans have been knocked off the top of the food chain, with disparate communities struggling for survival. American soldiers are being sent abroad to protect US interests from the Monsters, but the war is far from being won.
When carefree teenager Jay sleeps with her older boyfriend for the first time, she learns that she is the latest recipient of a fatal curse that is passed from victim to victim via sexual intercourse. Death, Jay learns, will creep inexorably toward her as either a friend or a stranger. Jay's friends don't believe her seemingly paranoid ravings, until they too begin to see the phantom assassins and band together to help her defend herself.