An infamous terrorist has evaded capture for a long time by being extremely clever and ruthless. Things get interesting when he hijacks a plane carrying famous security expert John Cutter, who isn't about to stand for this sort of thing.
Two uneasy friends, a police officer and a TV talk show host, each pursue the mysterious "handcuff killer" with the aid of an artist who sees - and draws - the killer's crimes before they're committed.
Fearful that their star witness might be murdered, two attorneys hire a protector to bring him from Los Angeles to New York. Jesse Crowder (Fred Williamson) is a no-nonsense tough guy. He buddies up with the witness, an accountant, and they hit the road. Outwitting their foes means taking all manner of conveyance, including automobile, train, and airplane.