The story is set at the blood donation club in Kurusu Private High School. There are four girls who are fascinated by the pleasure of having their blood drawn – Maki (Erika Karata), Jinko (Ichika Osaki), Nami (Mikoto Hibi), and Kaoru (Nazuki Amano). One day, Maki meets Mai (Nina Makino), a beautiful girl dressed in black, in the blood donation room. Mai fainted after her rampage against the nurses, and Maki unintentionally carries her into the blood donation club room. Mai then reveals a shocking fact – She is a dropout vampire who could not attack humans! Struck by Mai's fragile expression, Maki and other members decide to feed her with their own blood instead of donating blood…
21st Century Girl is an omnibus feature that is of the girls, by the girls and for the girls. The work of 15 women directors under the age of 30, each of whom contributed an 8-minute film, the package highlights a range of genres, visions and thematic concerns.
One day, Ezawa Jun, who has trouble with work and in love, gets a ryukin from a goldfish scooping game at a festival. However, she is actually a beautiful girl and she suddenly turns into a human form and appears in front of Jun. Called Ryu, she is looking for the legendary black ranchu and asks Jun for his help. The two strangers begin living together and growing closer. Their fate goes in an unexpected direction.
Haruki Bando decides to quit his family's sport of judo after a shoulder injury and start a new project with his childhood friend Kazuma. Together they form a cheerleading group called 'Breakers'.
College student Asako falls in love at first sight with Baku after meeting at a photography exhibit. Romance sparks between the two but doesn't last long when Baku suddenly disappears from her life. Two years later, she spots a man that bears a striking resemblance to him. Even though it is only his physical similarities to Baku that attracted her to him, she doesn't say so and starts dating the soft-spoken young man called Ryohei.
Asuka Goda is a 40-year-old pastry chef who runs a sweets store. She works with pastry chef Seiya Hanada, who is younger than her, and Kenichi Gonda, who wants to become a pastry chef. One day, Seiya Hanada confesses to Asuka Goda about his feelings for her. Her situation brings back bad memories to what happened 5 years earlier. At that time, Asuka Goda was in an affair with store owner Junji Awai and also in a relationship with gym trainer Shunsuke Nomura. Asuka Goda decides to go to mysterious "Clinic Love Doc." The clinic lets people know everything about love with a gene test.