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Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives
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On the set of a popular daytime soap opera 'Mile High', actress Kris Buckner is being forced off by co-star Mark Stratton. When she says that she'll 'kill him before she leaves the show', she makes herself the prime suspect when Stratton is murdered by someone poisoning him. As an old friend, Perry Mason comes to the help of Kris and agrees to defend her. Meanwhile Ken goes in search of information with the help of fan of the show.
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Dr Sheila Carlin is good friends with Della who calls Perry in when she is being pestered by someone. On the theory that it could be somebody that she works with at a radio stations she arranges Perry to be interviewed by Winslow Keene who is also the station's owner. Winslow enrages the rest of the talk show hosts on the station by informing them of changes that he is making to their time slots. That night, Winslow is shot by a hit man hired by someone at the station and Sheila is set up for the murder. She calls in Perry and as usual Perry, Della and Ken swing into action to find out who really did it.
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When '30s film star Thelma Todd dies mysteriously, her relationship with New York mobster Lucky Luciano is investigated.
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Diane and Greg Halstead were once happily married, even deciding to try and have a baby in later years, despite the fact that she had already suffered two miscarriages. She has no luck in becoming pregnant and this leads to an estrangement from her husband. On his latest flight, Greg, a professional pilot, finds out about a bomb threat. The person carrying the bomb supposedly wants to kill another passenger, a politician with an outspoken opinion on abortion. Unknown to the killer, however, the politician has already left the plane because it had an hour and a half delay. Greg decides to make an emergency landing in Dayton, Ohio, but during the heavy weather, the plane crashes, killing almost everyone on board.
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A young woman from Las Vegas wants Perry Mason to defend her father.
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Perry must defend the husband of an old flame from a murder charge.