Four years after the events of Halloween in 2018, Laurie has decided to liberate herself from fear and rage and embrace life. But when a young man is accused of killing a boy he was babysitting, it ignites a cascade of violence and terror that will force Laurie to finally confront the evil she can’t control, once and for all.
A young woman with psychokinetic powers breaks out of a Louisiana asylum and makes her way to New Orleans, where she falls into the city’s netherworld of misfits and miscreants.
The nightmare isn't over as unstoppable killer Michael Myers escapes from Laurie Strode's trap to continue his ritual bloodbath. Injured and taken to the hospital, Laurie fights through the pain as she inspires residents of Haddonfield, to rise up against Myers. Taking matters into their own hands, the Strode women and other survivors form a vigilante mob to hunt down Michael and end his reign of terror once and for all.
Laurie Strode comes to her final confrontation with Michael Myers, the masked figure who has haunted her since she narrowly escaped his killing spree on Halloween night four decades ago.