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A scientist, Dr Holander, takes his niece Miranda to Mexico in an attempt to reverse the effects of the alien DNA he used to create her. However the treatment goes horribly wrong, and sets Miranda on a killing spree as she sets out to find a mate.
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Two millennia ago, a Lybian king has a basilisk (snake-shaped dragon), which petrifies people, subjected to the same fate with a golden scepter during a solar eclipse. Both these and several victims are dug up by modern archaeologist Harrison 'Harry' McColl's expedition. Despite a cryptic warning from tribal locals, everything goes to his Colorado university's museum. It's all exhibited during another eclipse, which leads to the monster reviving. Harry and some of his friends must try to petrify the monster again.