The charismatic and self-confident man, Karel Král, is the editor-in-chief of men's magazine. Although a chauvinistic type, he is very popular with women. However, he struggles in his personal life. He frequently argues with his ex-wife over their 17 year-old daughter Julie, who despises his new way of life. Then the consequences of his behavior catch up with him. He loses his job, and the editor-in-chief position is given to a young and beautiful woman. But his bad luck does not end there. After another fight with his ex-wife and daughter, and a woman driver crashing into his car, Karel and his best friend Cestmír have an evening of binge drinking. During the wild night, he expresses a wish to be a woman. When he wakes up the next morning he discovers that his wish has been granted.
Josef and Miluška are married forever and ever. Miluška teaches aerobics and provides tirelessly care for her husband and teenage daughter. Joseph loves his wife, but also has a weakness for younger and more beautiful women. Their marriage, along with Joseph's bankrupt publishing house, is slowly crumbling. Aunt Marta, who has a mad plan to save both the collapsing marriage and the Joseph publishing house, comes to rescue. As an experienced psychologist working in a marital counselling, she directs her husbands to infidelity - they must be caught in flagranti. The crazy game can start.