Colic tells a story of a couple Pongpob and Phraeploy who have a shotgun wedding upon discovering that Praeploy has unexpectedly become pregnant. After the wedding, Pongpob brings Phraeploy to his mother's suburban home. The night before Praeploy delivers the child, the house next to theirs catches on fire. When the baby is delivered, and is brought to their house, he screams and cries with no reason. The doctor considers the baby has colic, and tells the couple that the ailment will disappear when the baby turns 3 to 6 months old. Several months later, the baby still hasn't stopped crying...while the family's members encounter to mysterious and unexplained experiences.
