An epileptic 12-year-old girl, Pippi, is hospitalized in the psychiatric ward instead of the neurological ward, due to an administration error. Out of this mistake begins the difficult journey towards being cured.
After twenty years of marriage, Gloria discovers that her husband has been cheating on her. It' a terrible trauma and she decides to stay with her sister in USA in St. Louis. She takes with her Matteo and Francesco, her two sons. Matteo wastes no time in settling into his new life, but Francesco find it more difficult, being shy and full of complexes.
Vittorio, an American novelist teaching in Rome, meets the beautiful but damaged Bianca and they rapidly fall into an urgent, tempestuous affair. He's hesitant over their relationship since she seems to thrive on conflict and is constantly baiting him into physical altercation. Bianca gives Vittorio an exquisite leather belt as a gift; he knows immediately that she wants him to whip her with it. Driven by his craving for her, Vittorio complies to Bianca's desire. Their relationship escalates into a dark realm of S&M which becomes more and more self-destructive.
A serial killer is terrifying the prostitutes in a big Italian city. After few barbaric murdering four prostitutes Lena, Angela, Nadine and Stella decide to unify and try to self-defend themselves. The police and all the other prostitutes agree with the four and the hunting is open. Who is the cruel killer?
Leo has a dream: to make a movie in the great outskirts of the metropolis (Rome). He does anything for money, including selling cocaine. But his dream vanishes in the night when the police catch his friend.