Fran likes to think about dying. It brings sensation to her quiet life. When she makes the new guy at work laugh, it leads to more: a date, a slice of pie, a conversation, a spark. The only thing standing in their way is Fran herself.
Finding himself down and out in Los Angeles, ex porn star Mikey Saber decides to crawl back to his hometown of Texas City, Texas, where his estranged wife and mother-in-law are living. Just as this dysfunctional family seems to be making things work, Mikey meets a young woman named Strawberry working the cash register at a local doughnut shop.
When a film crew moves into an abandoned psychiatric hospital with a shadowy past to shoot a low budget horror film, they get more than they bargained for. The late nights and lack of sleep begin to take a toll, and the longer this crew works, the more the leaky, wet building seems to be coming back to life, feeding off its new inhabitants. As the shoot wears on, members of the crew exhibit increasingly strange behavior leaving those still sane realizing they need to get out of this place before they too succumb to the building's infectious hold, the only problem, the old hospital is not ready to let them go.
World War II soldier-turned-U.S. Marshal Teddy Daniels investigates the disappearance of a patient from a hospital for the criminally insane, but his efforts are compromised by troubling visions and a mysterious doctor.