One night per year, the government sanctions a 12-hour period in which citizens can commit any crime they wish -- including murder -- without fear of punishment or imprisonment. Leo, a sergeant who lost his son, plans a vigilante mission of revenge during the mayhem. However, instead of a death-dealing avenger, he becomes the unexpected protector of four innocent strangers who desperately need his help if they are to survive the night.
A man suffering from borderline personality disorder is married to two women, who don’t know the other exists. As bills pile up and cracks start to show, the women independently start to suspect something is wrong.
Sikes and Francisco are called in to a case when a mysterious young girl, who looks part Newcomer, part human, appears. Her huge, brutish counterpart tries to free her from the precinct, and their bizarre relationship turns out to be the result of a slaveship medical experiment. Meanwhile, Cathy and Matt are going to sex school, in preparation of becoming intimate, while Buck distresses his parents by his anti-human opinions.
Who could have deliberately released a rare and deadly African plague that is now spreading uncontrollably throughout America's largest urban areas? A lone determined doctor desperately and fearlessly searches for the truth, but she soon finds herself targeted for death as well. With time running out to save human kind, Dr. Marissa Blumenthal discovers that the strange disease may have actually been unleashed by the medical establishment itself.
