Rizwan Khan, a Muslim from the Borivali section of Mumbai, has Asperger's syndrome. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his condition and his race.
Ishaan Awasthi is an eight-year-old whose world is filled with wonders that no one else seems to appreciate. Colours, fish, dogs, and kites don't seem important to the adults, who are much more interested in things like homework, marks, and neatness. Ishaan cannot seem to get anything right in class; he is then sent to boarding school, where his life changes forever.
DCP DeSilva sees a way to bring to justice the feared head of a criminal empire by recruiting a man named Vijay, who looks exactly like the crime boss. The ruse works too well, and soon Vijay finds his life in danger when DeSilva, the only one who knows his true identity, dies.