An American nurse living and working in Tokyo is exposed to a mysterious supernatural curse, one that locks a person in a powerful rage before claiming their life and spreading to another victim.
While driving, the pregnant horror-movie actress Kyôko Harase and her fiancé are in a car crash. She loses her baby and her fiancé winds up in a coma. Kyôko was cursed together with a television crew when they shot a show in the haunted house where Kayako was brutally murdered by her husband years ago. While each member of the team dies or disappears, Kyôko is informed that she has a three-and-a-half-month-old fetus in her womb.
Volunteer home-care worker Rika is assigned to visit a family, she is cursed and chased by two revengeful fiends: Kayako, a woman brutally murdered by her husband and her son Toshio. Each person that lives in or visits the haunted house is murdered or disappears.
