Five best friends from college reunite 10 years later for a wild bachelorette weekend in Miami. Their hard partying takes a hilariously dark turn when they accidentally kill a male stripper. Amidst the craziness of trying to cover it up, they're ultimately brought closer together when it matters most.
The death of the Kimbrough family matriarch affects the three male survivors of the clan. Widower Easy tries to reconnect with his old flame, Marg. Eldest son and struggling musician Guy moves back to town, feeling guilty that he missed the funeral. His brother, Beagle, who was his mother's caretaker, falls for Marg's granddaughter, Georgia, a chronically ill girl who fears her time is growing short.
Apartment building superintendent Cleveland Heep rescues what he thinks is a young woman from the pool he maintains. When he discovers that she is actually a character from a bedtime story who is trying to make the journey back to her home, he works with his tenants to protect his new friend from the creatures that are determined to keep her in our world.
Bree is about to get a sex reassignment surgery that will finally allow her to actually be what she’s already been in her mind for a long time: a transitioned woman. Yet before this happens she suddenly runs into her son who ends up coming for the trip across the United States.