Mitch Buchannon no murió en la explosión de una embarcación en la décima temporada, sino que sufrió una amnesia y se ha estado recuperando en Los Ángeles. Sorprendentemente... ¡Mitch regresa a Hawai con la intención de casarse! Su nueva novia, Allison, se parece mucho a la teniente Stephanie Holden, un antiguo amor. Lo que él no sabe es que Allison está colaborando con Mason Sato, uno de los villanos de la segunda temporada de la serie que regresa para vengarse.
Using footage left over from Nemesis 2 and a very thin story line sees Alex again fighting the cyborg mercenaries in 1998 East Africa. This time, Alex finds that she has 20 half sisters who are waiting for her to return to 2077. Central Command wants Alex captured alive and scanned to see if her DNA is a strong and more powerful strain than the normal. But Alex may be too tough for Farnsworth to capture.
It has been 73 years since Alex failed and the Humans lost the Cyborg Wars. Since then, the Humans have been enslaved. Scientists have developed a new DNA strain, which could signal the end of the Cyborgs, and they inject it into a volunteer. When the Cyborgs learn of the woman and the baby they list both for termination.