Según una antigua leyenda japonesa, sirena carne puede conceder la inmortalidad si se comen. Sin embargo, hay una probabilidad mucho mayor que el consumo dará lugar a la muerte o la transformación en una criatura maldita conocida como un alma perdida (o Seres deformes en el doblaje en Inglés). Mermaid Saga cuenta la historia de Yuta, un inmortal que ha estado vivo durante quinientos años, que está vagando a través de Japón en busca de una cura y conocer a otras personas cuyas vidas también han sido arruinada por carne de sirena en el proceso.
(voice)
When the bubbly 14-year-old Kotobuki falls in love with 26-year-old Hodaka, the owner and clothing designer of a popular boutique, she lies about her age in attempt to get closer to him. He is slow to warm up to her until a strange young man named Kazuomi asks Hodaka for part-time employment and stirs things up between them.
The elementary school student Rieko lives with her parents who are deaf and mute, and her younger sister. Rieko wishes to draw cartoons and comics that make people happy, and doodles comics of Bomberman and friends in her notebooks. An earthquake strikes during the night and ravages the city, leaving their neighbourhood a shambles. They travel to a shelter, but their parents' inability to hear and speak causes misunderstandings and conflict among the workers; Rieko helps resolve the situation while also keeping an eye on her younger sister. With support from volunteer worker Kyoko, an older girl from Tokyo, the community within the shelter begin to grow and understand one another. Rieko helps keep the younger ones amused with her drawings of Bomberman characters, including a comic of the heroes and villains putting their differences aside to help each other when the battle arena comes down on top of them.