A pair of women, one pregnant, face the myriad dangers of a post-nuclear winter world. They are searching for a rumored stronghold of civilization, known only as The Library, and must find it if the infant is to have any chance of survival.
Chris Redfield, de la BSAA, cuenta con la ayuda del agente del Gobierno Leon S. Kennedy y la profesora Rebecca Chambers del Instituto Alexander de Biotecnología, para parar a un mercader de la muerte que busca venganza, y amenaza con extender un virus mortal por Nueva York.
Ayane is the daughter of a karaage (fried food) store owner, but she never liked karaage. Eventually, she left home, only to return 5 years later. Her family lives in the city of Usa in Oita Prefecture, Japan. She brings with her a young girl named Shirley, who is her step-daughter from her ex-husband.
Unos extraños meteoritos caen alrededor de todo el mundo. Dichas rocas parecen tener algo especial por lo cual seres extraños aparecen para tomar lo que hay de ellos. Los Siete Riders Legendarios intentan defender lo que hay en ese lugar, pero no pueden y la Organización X toma poder sobre eso. A la vez, Eiji tiene que volver a la acción ya que un rider del futuro ha llegado para eliminar a todos los riders. Por su parte, Gentarou y sus amigos reciben la visita de una extraña chica. Sus caminos se cruzarán junto con el del detective W .
Haiji was an elite runner, but has not competed due to a past injury. He then meets fellow elite runner Kakeru who also left running, but caused by a dispute. Their meeting inspires both young men to run again, with Haiji choosing the fabled "Hakone Ekiden" (long distance relay race). The race requires a 10 member team so Haiji and Kakeru recruits 8 others (some of whom have never even run before). Within this unlikely group of runners a bond is formed through their training and a belief that they can accomplish the impossible.
ER doctor Tsuyoshi Matsuoka receives a patient with a virus unlike anything he's seen before. His symptoms include high fever, convulsions, vomiting of blood and multiple organ failure. Could this be a new form of influenza or is it some other variety of virus? As the situation worsens and more cases begin arriving, a medical officer from the World Health Organization named Eiko Kobayashi is dispatched to the area. At the rate the virus is spreading, the entire city’s transportation system and infrastructure would be brought to a halt within 3 months. Within 6 months it could spread to tens of millions of people--reaching a death toll far worse than any war.