Veteran western performers Harry Carey and Marguerite Clayton appeared in three films together from 1923-1924: Desert Driven, Tiger Thompson and, perhaps their best, Canyon of the Fools.
John Wesley Pringle, aventurero en libertad, regresa a casa después de hacer su ataque y encuentra a su vieja amiga, Stella, comprometida con Christopher Foy, quien se postula para sheriff. Pringle frustra un intento del sheriff titular Matt Lisner de matar a Foy, pero cuando Foy es acusado de un asesinato, Pringle, en una astuta treta, captura a Foy, mantiene a la pandilla a punta de pistola y luego lo libera, explicando su motivo.
Coming upon a burning cabin, David Brent discovers the body of Jim Drew, who had been killed in a fight with a drunken Indian. Brent finds in Drew's pocket a letter announcing the impending arrival of Drew's daughter Lorelei. Feeling an obligation to Drew, who once saved his life, Brent journeys to San Francisco to meet Lorelei, who mistakes him for her father. Brent cannot bring himself to break the bad news to her and does not correct her false assumption.
Dick Rainboldt (Carey) signs up to work at a gold mine without realizing that he's being hired as a strikebreaker. He takes the job primarily because of a pretty girl who lives in the town. The superintendent and manager of the mine convince Rainboldt to blow up the mine and make it appear like the strikers did it. But Rainboldt turns the tables on the plotters and reveals their scheme. The mine owner rewards him with a big assignment and the girl promises to marry him.
Hobo poet Sundown Slim meets his old friend Billy Corliss in a Western saloon. Billy, in poor health as a result of injuries sustained in a train wreck, now owns the Concho cattle ranch with his brother Jack who runs the ranch. Sundown obtains a job at the Concho and becomes embroiled in the Corliss' battle with their sheeprancher neighbors, the Fernandos. When Loring, one of Jack's employees, attacks Fernando's daughter Anita, Jack fires him but Fernando, not satisfied, vows revenge on Jack, then shoots Billy by mistake.