Kuriki
Rin is a popular singer. He is about to propose to his girlfriend Mami, but they get into an argument. Rin runs out of the home and, while walking around, he suddenly goes down in the middle of a crosswalk. Takehito is the vocalist of unpopular indie band "Even" and he happens to see Rin on his hands and knees at the crosswalk. Rin tries to help him get up, but they are involved in a car accident. When Rin wakes up at the hospital, he sees himself laying in the hospital bed unconscious. He realizes that he is in Takehito's body. To Let Mami know that he is in Takehito's body and to send her his love, he begins to write a song with the members of "Even."
Kanami is an apprentice pierrot and dreams of making people laugh. She falls in love with Yosuke who is a dialysis patient. He forgets to smile. To make Yosuke smile, Kanami decides to have a smile no matter what. Yosuke begins to have feelings to her and they decide to marry. On the day before their wedding Yosuke collapses.
Nurse Mika
There is a darkness in Fukie's body that grows and spreads to all who touch her life.
The Story of the 1 Litre of Tears special takes place after the events in the main drama. The Special takes the view of Asou Haruto who is remembering life the way it used to be before the events of the last episode of the series.
A meek agent at the Showa Life Insurance company receives a phone call from a customer who says that she's planning to commit suicide and wants to know if her policy will pay out. Concerned about her safety, the agent visits her house only to find that her young son has hanged himself. As he investigates further, more and more people connected with this family start having "accidents," and if he's not careful, he might be next.
