One day during summer vacation, a palm-sized alien named Papi appears from a small rocket that Nobita picks up. He is the president of Pirika, a small planet in outer space, and has come to Earth to escape the rebels. Doraemon and his friends are puzzled by Papi’s small size, but as they play together using the secret tool “Small Light”, they gradually become friends. However, a whale-shaped space battleship comes to earth and attacks Doraemon, Nobita and the others in order to capture Papi. Feeling responsible for getting everyone involved, Papi tries to stand up to the rebels. Doraemon and his friends leave for the planet Pirika to protect their dear friend and his home.
Toda la tripulación femenina de la nave de transporte Muse está en una misión en el espacio profundo. Recogen una señal de SOS y descubren un crucero espacial abandonado donde todas las mujeres han muerto misteriosamente. Se llevan al único sobreviviente, una joven llamada Flair, y detonan el barco fantasma. Sin embargo, el peligro apenas comienza. Con Flair on the Muse, los romances entre las mujeres comienzan a tomar un nuevo giro. Uno por uno, los tripulantes son atacados por una misteriosa presencia alienígena, desesperados por encontrar una manera de reproducirse con mujeres humanas.
