A thirty-six year old radio show host embarks on a cross-continent search to find herself, in the process discovering that her sex is "stuck" and waging a valiant effort to release it while simultaneously accomplishing her many unmet goals in life. Carolina (Beatriz Rico is in her mid-thirties, and her life is falling apart fast: not only has annoying blonde Lula (Imma del Moral) been recruited to take over the show that Carolina created, but the besieged hostess is beginning to feel that time is running out for her to chase down the dreams of her forgotten youth. In search of guidance, Carolina turns to openly gay carpentry shop owner Compass Rose (Jorge Luis Gonazáles). Compass is Carolina's best friend, and while his advice often veers towards the hysterical side, the two quickly hatch a plan to travel to India in search of a guru.
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Hank Chinaski envía sus poemas y relatos a revistas literarias, que rechazan siempre su trabajo. Para pagar su modesto alojamiento y su adicción al alcohol, realiza trabajos eventuales como obrero, portero o taxista. Su principal objetivo nunca fue ganar dinero para vivir lujosamente; lo que a él le gusta es apostar en el hipódromo, poder amar a dos mujeres (Jan y Laura) tan aficionadas al alcohol como él, observar las pequeñas cosas y, sobre todo, escribir. Cuando Jan lo abandona por otro hombre, Hank recibe la inesperada llamada de una prestigiosa revista literaria.
