Bruno Salvati is a director of little success, fresh from the separation from his wife Anna with whom he had two children, the twenty-year-old Adele and the seventeen-year-old Tito. Following a sudden illness, Bruno is diagnosed with a disease that requires the intervention of a donor. All his family relationships are called into question, including that with his father Umberto, the custodian of a secret that will force Bruno to embark on a journey in search of someone who can help him.
Samantha (Valentina Bellè) es secuestrada en mitad del camino a casa por un conejo gigante. Quince años después se despierta en la cama de un hospital. Aunque está en shock, pronto comprende que lo más importante que está con vida, sobre todo gracias a la ayuda del Doctor Green (Dustin Hoffman), que intenta guiarla por el arduo camino de la recuperación de memoria. Entre los dos dibujan el diseño del laberinto, una prisión subterránea aparentemente sin salida en la que "alguien" obligó a la pobre Samantha a resolver puzles y acertijos. Bruno Genko (Toni Servillo), un inspector privado de enorme talento, decide participar también en el caso. Aunque no le queda mucho con vida, Bruno trata de ofrecer lo mejor de sí mismo dado que piensa que este será su último caso.
Marco Parisi have worked in a small Turin factory for thirty years. The bankruptcy trustee gives him a year to seek investors keeping the company alive. At the end of the year, it is Marco himself who decides to take over.