En un futuro próximo, se ofrece a presidiarios la oportunidad de someterse a experimentos médicos para acortar su sentencia. Uno de los sujetos, inyectado con una droga que genera sentimientos de amor, empieza a cuestionar sus emociones.
Emily is a recovering cancer survivor of three years. Faced with her fear of getting sick again, her best friend Nina plans a weekend away. Six friends venture out to a country holiday house to party over a weekend. Cut off from the rest of the world they soon learn the inhabitants are unsettling red neck individuals who terrorize and humiliate travelers. At the same time a para-normal monster seen as the faceless man haunts the house pushing the friends to their limits.