Narra las disputas políticas entre Herr Roloff, un ultraconservador empresario, el cual tiene una hermana de izquierdas... y el profesor Johannes, el cual siente un compulsivo y secreto amor por la mujer de Herr Roloff; todos ellos se hallan al borde de un abismo psicológico y moral, almas atormentadas que viven sus vidas en un atormentado país.
Part of the artificial-creature series encompassing Der Golem (1914 and 1920), Alraune (1918, 1928, 1930) and Metropolis (1926), 'Homunculus' was the most popular serial in Germany during World War I even influencing the dress of fashionable Berlin. Foenss, a Danish star, is the perfect creature manufactured in a laboratory by Kuehne. Having discovered his origins, that he has no 'soul' and is incapable of love, he revenges himself on mankind, instigating revolutions and becoming a monstrous but beautiful tyrant, relentlessly pursued by his creator-father who seeks to rectify his mistake.