Tras un experimento militar fallido, el oficial Joe Bawers (Luke Wilson) y la prostituta Rita (Maya Rudolph) despiertan quinientos años adelante en el futuro, en un mundo distópico en el que la selección natural ha favorecido a los más idiotas, debido a que se reproducen más. Esto ha resultado en una humanidad estúpida e ignorante, de modo que Joe descubre que es el hombre más inteligente del planeta. Pronto se convierte en un cercano consejero del Presidente de los Estados Unidos, el excéntrico Camacho (Terry Crews).
The Face of the Serpent is an action-thriller with strong political undertones of local government corruption. The film focuses on a morally conscious assassin called Quinn. His next target is a Russian immigrant named Tasha, whom Quinn is misled into believing is a drug courier. During Quinn's surveillance of Tasha, planning for the perfect moment to make his kill, he becomes infatuated with her beauty and pure innocence. Ultimately, Quinn rescues Tasha from the hands of another assassin and takes her into his protection. The two join forces to find out who wants her dead and why. In the process, Quinn discovers secrets from his past and battles with the inner demons that made him the man he is today.
