Dee (Pamela Anderson) y Dawn (Denise Richards) son dos explosivas rubias que son confundidas con una conocida pareja de asesinas profesionales. Entonces recibirán el encargo de acabar con la vida de Mr. Wong, un capo de la mafia china. Tras unos momentos de indecisión, se lanzarán a la aventura más loca de sus vidas.
J.W. Garrison, the head of a top-secret sub agency of the United Nations, discovers that a team of terrorists, led by the murderous Oliver Maxwell, plan on producing a bomb carrying an anthrax virus to be used in the United States. Garrison summons CIA agent Zack Hamilton who puts together a team of three beautiful women; CIA trainer Kim Taylor; photographer Victoria Carrera; and actress Eva Kirov to go to undercover as fashion models to infiltrate the terrorist organization to find the bomb before it can be used.