El film empieza cuando un misterioso virus ataca una escuela aislada, transformando a los niños preadolescentes en un enjambre de salvajes estúpidos. El menos esperado de todos deberá liderar a los profesores en una lucha por sus vidas contra estos monstruosos alumnos.
Dos médicos responden a la llamada de una niña que dice que su madre ha sido herida. Cuando llegan al lugar, una zona totalmente desierta, los dos hombres son secuestrados por una secta religiosa cuya gran obsesión es parar el fin del mundo suicidándose y matando a todos.
Tweek City is a week in the life of Bill, a potentially closeted, half-Latino, small-time speed dealer in San Francisco's Mission District. Bill is stuck on an endless walk from one empty experience to the next. Only Bill's friend Jerm has the ability to connect and ground him in reality. When Jerm makes an ill-advised stage dive, Bill plunges into a downward spiral that takes him on a nocturnal journey through the streets of San Francisco and ultimately down to Los Angeles where he crashes his high school sweetheart's wedding. From his sleep-deprived, hallucinogenic state, Bill fails miserably in a desperate attempt to reconnect with his first and only love. With nowhere else to go, Bill jacks a car and ends up at the deserted drive-in theater of his childhood where he is forced to confront the ghosts that he had tried to leave behind.
