Teenagers from a small town and their high school science teacher join forces to battle a giant mutant spider, living in a cave nearby and getting hungry.
Glenn Manning, "The Amazing Colossal Man," believed dead after falling from the Hoover Dam, reemerges in rural Mexico, brain damaged, disfigured, and very angry.
The mysterious Mrs. Eleanor Carter moves to Springville with her two teenage children Jimmy and Cathy. Eleanor makes friends with the town's social leader Mrs. Wellington, who supports her idea for a town youth center, and she is aided by Tom Griffith, the high school principal. At the town's annual picnic, to which Eleanor has bought a band, the town busy-body Eunice reveals what she had learned from Eleanor's past.
Lt. Col. Glenn Manning is inadvertently exposed to a plutonium bomb blast and although he sustains burns over 90% of his body, he survives. Then he begins to grow, but as he grows he starts losing his mind. By the time he stops he is 50 ft tall, insane and is on the rampage.
The eccentric Bullock household again need a new butler. Daughter Irene encounters bedraggled Godfrey Godfrey at the docks and, fancying him and noticing his obviously good manners, gets him the job. He proves a great success, but keeps his past to himself. When an old flame turns up Irene's sister Cordelia starts making waves.