Ten years after the first American Pie movie, three new hapless virgins discover the Bible hidden in the school library at East Great Falls High. Unfortunately for them, the book is ruined, and with incomplete advice, the Bible leads them on a hilarious journey to lose their virginity.
Walter is a rising star in the NCAA wrestling world until his life is ripped apart by the brutal murder of his sister. Returning home to console his mother Gloria he seeks vengeance on the man who is accused of the crime. A chance meeting with a beautiful mature woman gives him solace to the situation. Will this unlikely pairing bloom into a romance and heal a wound the world cannot see or will the loss of his sister push him over the edge?
The mother of a young divorcee places an ad on her daughter's behalf on a lonely hearts internet website but the person who responds fits her own ideal of a suitable partner. The daughter is still hung up on her musician ex-husband.