Jessica Nieves-Sanders, a high school drama teacher in Queens, longs to be a mother before she hits 40. After several failed attempts at IVF she is forced to explore alternative methods to become one.
Alexander's day begins with gum stuck in his hair, followed by more calamities. Though he finds little sympathy from his family and begins to wonder if bad things only happen to him, his mom, dad, brother, and sister all find themselves living through their own terrible, horrible, no good, very bad day.