Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon on the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.
A young man named Eric apparently dies in a suspicious house fire after saving his girlfriend, Melody. One year later, a new mall is constructed atop where Eric's house once stood, where a shadowy, uninvited guest is preying on the mall's crooked developers.
After Leila, his boss's daughter, is kidnapped by psychopathic plague victim Decker, chauffeur Chazz teams up with plague-infected mercenary Luger to penetrate the toxic & off-limits Plague Zone and bring her back alive.