Kindhearted Griffin Keyes is one of the best-loved caretakers at the Franklin Park Zoo, but since he is more comfortable with the animals than with females of his own species, his love life is lacking. When Griffin decides that the only way to get a girlfriend is to find a more-glamorous career, the animals panic. To keep him from leaving, they reveal their secret ability to talk and offer to teach him the rules of courtship, animal-style.
When high school football player Cam Stiles loses his best friend, he decides to drop football and focus on attaining his friend's goal of running a mile in under four minutes. Cam's decision tears apart his relationship with former teammates and his father—who happens to be his demanding football coach.
Set over a single day and night in a small, Manhattan hotel, this story leads us through the lives of its temporary inhabitants. As the paths of these strangers cross, they become connected.