Rio Kusumo (Dimas Aditya) is a pessimistic young man. One day, he suddenly takes part in a marathon race and meets a girl named Anisa (Olivia Jensen). Anisa invites Rio to run and they must finish the marathon on the slopes of Mount Bromo.
'Isyarat' takes the innovative approach of bringing together five young directors, Asmirandah, who made Teman Bayangan (Shadow friend); Monty Tiwa (Lost and Found); Adhyatmika (Flora); Donny Alamsyah (Tanda Bahaya or Alarm); and Reza Rahadian (Gadis Indigo or Indigo girl), to create a series of separate but interconnected supernatural tales.