In Los Angeles, siblings Ellie and Jimmy come across an accident on Mulholland Drive. As they try to help the woman caught in the wreckage, a ferocious creature attacks them, devouring the woman and scratching the terrified siblings. They slowly discover that the creature was a werewolf and that they have fallen victim to a deadly curse.
When Maggie's sister Jenna saddles her with an autistic newborn named Cody she touches Maggie's heart and becomes the daughter she has always longed for. But six years later Jenna suddenly re-enters her life and, with her mysterious new husband, Eric Stark, abducts Cody. Despite the fact that Maggie has no legal rights to Cody, FBI agent John Travis takes up her cause when he realizes that Cody shares the same birth date as several other recently murdered children.