Mattie Austin
Blind Ambrose North is tormented by the suspicion that his wife Constance committed suicide when their crippled daughter Barbara was only two, because she did not love him. Before her death, Constance wrote Barbara a letter to be opened on the girl's twenty-first birthday, but when Barbara opens it and learns that her mother killed herself to escape a doomed love affair with Lawrence Austin, she invents a different story for Ambrose, knowing that the truth would hurt him too deeply.
Mrs. Bertha Randall
When a burglar dressed as Santa Claus steals a family's Christmas presents, amateur detective Octavius sets out to recover the loot.
the maid
Mrs Grayson accidentally leaves her baby son at a shop and flies into a panic when she returns home to find him missing.
The Waitress
A son wants more out of life, but Dad does not.
His tenant, Widow Dugan
A printer and his young assistant take over a local newspaper while the editor is away.
Daisy
The forerunner of all serials, What Happened to Mary was a series of twelve monthly one reel episodes, each a complete entity in itself, revolving its immediate dramatic and melodramatic problems within the framework of a single episode and designed more for story and suspense situations than action.