A young British widow shelters an old medical school colleague, a man who has somehow turned himself invisible. As his isolation grows and his sanity frays, he schemes to create a reign of wanton murder and terror across the city.
Penny works at a supermarket and Phil is a gentle taxi-driver. Penny’s love for Phil has run dry and they lead joyless lives with their two children, Rachel, a cleaner, and Rory, who is unemployed and aggressive.
Although married and pregnant Rose has always been mother's favorite, it is younger sister Iris whose life is shaken up by mother's death. Suffocating, Iris spirals out of control and copes by losing herself in sexual oblivion.
A beautiful young dentist working in a tough British prison starts to become attracted to a violent inmate after the break-up of her marriage, and embarks upon an illicit affair with him, with terrible consequences for all.