For a long time, Natalie, an Australian architect living in New York City, had always believed that what she had seen in rom-coms is all fantasy. But after thwarting a mugger at a subway station only to be knocked out while fleeing, Natalie wakes up and discovers that her life has suddenly become her worst nightmare—a romantic comedy—and she is the leading lady.
When her husband is sentenced to eight years in prison, Ruby drops out of medical school in order to focus on her husband's well-being while he's incarcerated - leading her on a journey of self-discovery in the process.
Bertram Pincus, a cranky, people-hating Manhattan dentist, develops the unwelcome ability to see dead people. Really annoying dead people. Even worse, they all want something from him, particularly Frank Herlihy, a smooth-talking ghost, who pesters him into a romantic scheme involving his widow Gwen. They are soon entangled in a hilarious predicament between the now and the hereafter!